288 Articles with the topic: Methodology of Medical Research
Joining forces to improve lung cancer treatment
piggy submitted, created time 1 year 4 months (www.eurekalert.org)
Prevention, personalized therapies and closer collaborations between surgeons, medical oncologists and radiation oncologists will result in better outcomes for lung cancer patients and those at risk, a leading European expert says.
"Lung cancer is a complex disease. It is one of the most complex cancers, and the more we learn about the biology of the disease, the more we realize that improved cancer care will result from multidisciplinary treatment," said Prof Robert Pirker, from the Medical University of Vienna, Austria 
piggy submitted, created time 1 year 4 months (www.eurekalert.org)
Researchers from the University of Michigan Comprehensive Cancer Center have found a new way to examine brain tumor treatments. Their imaging system can predict probably patient longevity as early as one week after initial treatment.
Instead of creating a composite view of average change within the tumor, this method uses a standard magnetic resonance imaging protocols to monitor changes in tumor blood volume over time within the image's individual voxels
Breakthrough model for human cancer may improve development of cancer drugs
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in which AVEO successfully created invasive human tumors from primary human breast tissue. These tumors are placed in test mice, where they develop over time, mimicking the progress and responses of human tumors. The findings were published this week in the early edition of the Proceedings of the National Academy of Sciences.
Light reveals breast tumor oxygen status
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
Light directed at a breast tumor through a needle can provide pathologists with biological specifics of the tumor and help oncologists choose treatment options that would be most effective for that individual patient.
Duke University bioengineers have developed a light-based system that can quickly and easily provide important information about oxygen levels within a tumor while it is still in place. The new system, based on diffuse reflectance spectroscopy, gives researchers important clues about the tumor by interpreting how the light is either reflected back from the tumor or absorbed
Transforming medical diagnosis with new scanning technology
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
Scientists at the University of York have developed a new technology that dramatically improves the sensitivity of magnetic resonance techniques, including those used in hospital scanners and chemistry laboratories.
Ultimately, this technique, based on manipulating parahydrogen, best known as the fuel used on space shuttles, is expected to lower costs while increasing the range of medical conditions that can be examined.
The research is published in the latest edition of the journal Science.
Living Model of Basic Units of Human Brain Created
piggy submitted, created time 1 year 5 months (www.sciencedaily.com)
Researchers in the School of Life & Health Sciences at Aston University in Birmingham, UK are developing a novel new way to model how the human brain works by creating a living representation of the brain.
They are using cells originally from a tumor that have been reprogrammed to stop multiplying. Using the same natural molecule that the body uses to stimulate cellular development, the cells are turned into a co-culture of nerve cells and astrocytes - the most basic units of the human brain
European clinical trial rules under fire
sea-maid submitted, created time 1 year 5 months (www.nature.com)
The European Clinical Trials Directive has been in place for five years. Lead scientists are claiming that the law, which was put in place to improve trials and "harmonize" (read: standardize) trial procedures, is costing lives by slowing down vital research and driving the most promising scientists out of the E.U.
The law lays down what its makers seem to have believed to be the best procedures for ethical matters, such as obtaining informed consent and dealing with dangerous drug reactions.
Magnetic Nanoparticles Navigate Therapeutic Genes Through the Body
sea-maid submitted, created time 1 year 5 months (www.sciencedaily.com)
Scientists of the national German metrology institute, the Physikalisch-Technische Bundesanstalt (PTB), have developed a highly sensitive means of measuring the efficiency of gene transfer in cases if cardiovascular diseases.
What tenure used to mean at medical schools--and doesn't any more
Darkfrog submitted, created time 1 year 5 months (sciencecareers.sciencemag.org)
The role of tenure and tenure-track status in U.S. medical schools has changed and continues to change. Due to an increase in the number of hires, the percentage of tenured and tenure-track faculty has dropped ...with one interesting side effect.
It used to be that if an applicant checked "No" on the "Do you hold a tenured or tenure-track position," then his or her grant or job application would be chucked in the recycle bin (or the wastebasket, depending on the period)
Blood test predicts chance of dementia
piggy submitted, created time 1 year 6 months (www.eurekalert.org)
Frontal lobe dementia (Frontotemporal Dementia, FTD) strikes people at an earlier age than other forms of dementia. After Alzheimer's disease, FTD is the most common form of dementia in patients under sixty-five. The disease process starts in the frontal lobe, the section of the brain located toward the front of the head, where large numbers of brain cells begin to die off.
Among other things, the frontal lobe is involved in regulating behavior, movement and mood. It is also responsible for cognitive functions such as language
DNA cassettes yield safer induced pluripotent stem cells
Darkfrog submitted, created time 1 year 6 months (www.nature.com)
Induced pluripotent stem cells, which are adult cells that have been regressed backwards so that they act like embryonic stem cells, usually require the use of viruses to insert the genes required to activate embryonic-stem-cell-like activity. Although these viruses are altered so that they cannot reproduce outside of controlled conditions, they still present enough danger to render the use of iPS impractical in medicine.
However, a new study out of Mt. Sinai hospital reveals another means of regressing adult cells
Dark Cells of Living Retina Imaged for the First Time
piggy submitted, created time 1 year 6 months (www.sciencedaily.com)
A layer of "dark cells" in the retina that is responsible for maintaining the health of the light-sensing cells in our eyes has been imaged in a living retina for the first time.
The ability to see this nearly invisible layer could help doctors identify the onset of many diseases of the eye long before a patient notices symptoms. The findings are reported in Investigative Ophthalmology and Visual Science on February 26, 2009.
MRI modified for better images
sea-maid submitted, created time 1 year 6 months (www.nature.com)
A simple change to magnetic resonance imaging (MRI) machines will provide more uniform coverage at higher powers as well as more room for portly patients. In a market set to be worth more than $5 billion by 2010, the new technology may offer an easier way to get to the high-field machines manufacturers and clinicians see as the next target for hospital imaging.
Boosting its infectivity turns benign virus into good gene therapy carrier for cystic fibrosis
piggy submitted, created time 1 year 6 months (www.eurekalert.org)
Researchers from the University of California, Berkeley, and the University of Iowa have turned a relatively benign virus into a highly infectious form that is ideal as a carrier for gene therapy. In its first gene therapy test, it completely cured human cystic fibrosis lung tissue in culture
sea-maid submitted, created time 1 year 6 months (www.sciencedaily.com)
University of Washington researchers have helped develop a new kind of microscope to visualize cells in three dimensions, an advance that could bring great progress in the field of early cancer detection. The technique could also bridge a widening gap between cutting-edge imaging techniques used in research and clinical practices, researchers said.
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