Articles with the keyword: 
Protein identified as critical to insulating the body's wiring could also become treatment target
piggy submitted, created time 9 months 3 weeks (www.scienceblog.com)
A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer, Medical College of Georgia researchers say.
They report this week in Proceedings of the National Academy of Sciences Online Early Edition that in the peripheral nervous system that controls arms and legs, the protein erbin regulates the protein neuregulin 1, stabilizing and interacting with the ErbB2 receptor on Schwann cells so they can make myelin, which insulates the wiring 
Protein Could Provoke Immune Attack On Several Cell Types
sea-maid submitted, created time 10 months 1 week (www.sciencedaily.com)
Autoimmune disease is a condition in which the immune system attacks the body’s own material just as aggressively as it would attack a foreign pathogen. Multiple sclerosis, MS for short, is just one such autoimmune disease, and is one of the most common neurological diseases in the 20 to 30 years age group. The disease can have very severe consequences for those afflicted, since the body’s defenses attack the central nervous system.
Penn biologists discover how silent mutations influence protein production
piggy submitted, created time 11 months 1 week (www.eurekalert.org)
Biologists at the University of Pennsylvania have revealed a hidden code that determines the expression level of a gene, providing a way to distinguish efficient genes from inefficient ones. The new research, which involved creating hundreds of synthetic green-glowing genes, provides an explanation for how a cell "knows" how to make just the right amount of protein to maintain homeostasis yet not so much as to cause cell toxicity
Plastic protein protects bacteria from stomach acid's unfolding power
piggy submitted, created time 11 months 3 weeks (www.eurekalert.org)
A tiny protein helps protect disease-causing bacteria from the ravaging effects of stomach acid, researchers at the University of Michigan and Howard Hughes Medical Institute have discovered.
Their findings were scheduled to be published online in the Proceedings of the National Academy of Sciences the week of March 23.
Stomach acid aids in food digestion and helps kill disease-causing bacteria. One way that acid kills bacteria is by causing the proteins in them to unfold and stick together in much the same way that heating an egg causes its proteins to form a solid mass
piggy submitted, created time 1 year 1 week (www.eurekalert.org)
The function of a protein is determined not only by its structure but also by the other molecules with which it interacts inside the cell. Up until now, analyzing a protein's structure and function has required that the proteins be isolated, removing any chance of directly factoring interactions into the equation.
An international team of researchers from Tokyo Metropolitan University, Goethe University, and the Frankfurt Institute for Advanced Studies (FIAS) has, for the first time, determined the structure of a protein without removing it from its natural environment, the living cell
sumsung submitted, created time 2 years 2 weeks (sciencenow.sciencemag.org)
Researchers have unearthed new clues behind a disease that effectively turns young children into senior citizens. A protein called progerin prods stem cells to go astray, causing them to mature into the wrong cell types. The findings may have implications for understanding normal aging as well.
The reticulons: a family of proteins with diverse functions
zibba submitted, created time 2 years 2 months (genomebiology.com)
The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids, but reticulon amino-terminal domains display little or no similarity to each other.
How were DNA and protein molecules formed during the process of the origin of life?
pang xiaofeng submitted, created time 2 years 4 months (www.discover8.com)
We propose a new mechanism for the formation of DNA and protein molecules in the process of the origin of life based on the discovery of clustered chain structures of water molecules of size 2-70nm which exist in addition to the free molecules present in water. We suggest that not only was water a suitable environment for the appearance of DNA and protein molecules in primordial times but also that water molecules, with their clustered chain structures, were the templates for the formation of DNA and protein molecules
sumsung submitted, created time 2 years 4 months (www.pnas.org)
Protein quality control is accomplished by inducing chaperones and proteases in response to an altered cellular folding state. In Escherichia coli, expression of chaperones and proteases is positively regulated by δ32.
brooke submitted, created time 2 years 4 months (www.pnas.org)
Ovarian cancer is a leading cause of deaths, yet many aspects of the biology of the disease and a routine means of its detection are lacking. We have used protein microarrays and autoantibodies from cancer patients to identify proteins that are aberrantly expressed in ovarian tissue.
A search for biomarkers for early detection of colorectal cancer
william submitted, created time 2 years 5 months (www.eurekalert.org)
Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified in colorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer.
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event
davis submitted, created time 2 years 6 months (www.pnas.org)
In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7) physiologically phosphorylates mammalian and yeast proteins.
jackson submitted, created time 2 years 6 months (www.pnas.org)
The signal-recognition particle (SRP) is a ubiquitous protein–RNA complex that targets proteins to cellular membranes for insertion or secretion. A key player in SRP-mediated protein targeting is the evolutionarily conserved core consisting of the SRP RNA and the multidomain protein SRP54.
Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice
stephen submitted, created time 2 years 6 months (www.pnas.org)
Tamalin is a scaffold protein that interacts with metabotropic glutamate receptors and the kinase-deficient neurotrophin TrkCT1 receptor and forms a protein complex with multiple protein-trafficking and intracellular signaling molecules.
Protein that removes plaque holds promise for Alzheimer's patients
merry submitted, created time 2 years 7 months (www.cbc.ca)
Scientists from the University of Rochester Medical Centre in Rochester, N.Y., performed studies on mice with a buildup of amyloid-beta, a toxic plaque that builds up in the brains of Alzheimer's sufferers and damages them.
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