Autism spectrum disorders (ASDs) are common, heritable, but genetically heterogeneous neurodevelopmental conditions. The researchers recently defined a susceptibility locus for ASDs on chromosome 1q41-q42. They found that MARK1 was overexpressed in the prefrontal cortex (BA46) but not in cerebellar granule cells, on postmortem brain tissues from patients. Thus, MARK1 overexpression in humans may be responsible for subtle changes in dendritic functioning.
From this resport, we know that like parents sending their child off to college, a dividing cell has to let its offspring go. A microtubule-organizing protein helps ensure that the daughter cell breaks free.
From this study, the scientist found CENP-E, an essential microtubule motor that clings to the kinetochore. It was used to explain how chromosomes retain connections to the microtubules that help move them around.
This paper is about a monopolar HeLa system which is used to determine how the cytokinetic furrow is created. From the research,the author tells us that splitting mitotic cells in two is not the one-way signaling road it once seemed, based on evidence from Hu et al.
The microtubule cytoskeleton is essential to cell morphogenesis. Growing microtubule plus ends have emerged as dynamic regulatory sites in which specialized proteins, called plus-end-binding proteins (+TIPs), bind and regulate the proper functioning of microtubules.
During mitosis, kinetochores attach chromosomes to the tips of growing and shortening microtubules. Asbury and colleagues demonstrate that the level of tension applied through optical tweezers to the budding yeast kinetochore component Dam1 attached to a microtubule tip determines parameters of microtubule dynamics and ultimately, the length of the mitotic microtubules.