Articles with the keyword: 
Skin cancer study uncovers new tumor suppressor gene
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cancer and many other types of cancer.
The NIH analysis found that one-quarter of human melanoma tumors had mutations in genes coding for matrix metalloproteinase (MMP) enzymes 
New Measure for Malignancy of Melanoma
sea-maid submitted, created time 1 year 5 months (www.sciencedaily.com)
Every tumor, starting from a size of a few millimeters, depends on a supply of nutrients and oxygen. This is why tumors use special growth factors to induce the vascular wall cells of neighboring blood vessels to sprout new capillaries in their direction. The study discussed in this article explores the role of angiopoietin-2 (Ang2) in this type of angiogenesis.
Drugs from Vegetables May Target Melanoma Tumors
sea-maid submitted, created time 1 year 6 months (news.yahoo.com)
A drug based on isothiocyanates extracted from cruciferous vegetables such as broccoli and cabbage could offer a potent and safe treatment against melanoma, Penn State College of Medicine researchers say.
Recent mouse model experiments found that treatments involving both isothiocyanates and selenium reduced tumor growth by about sixty percent by interfering with a protein called Akt3.
The specific drug used in these tests was not an isothiocyanate, but a construct called isoselenocyanate
Beach vacations may increase future skin cancer risk in children
piggy submitted, created time 1 year 7 months (www.eurekalert.org)
Vacationing at the shore led to a five percent increase in nevi (more commonly called "moles") among seven-year-old children, according to a paper published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.
Number of nevi is the major risk factor for malignant melanoma, the most dangerous form of skin cancer. Melanoma rates have been rising dramatically over recent decades. More than 62,000 Americans are diagnosed with melanoma each year and more than 8,000 die
Jefferson scientists discover a key protein regulator of inflammation and cell death
piggy submitted, created time 1 year 7 months (www.eurekalert.org)
Reporting in the journal Nature, researchers led by Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation.
The protein, AIM2 (absent in melanoma 2), is involved in the detection and reaction to dangerous cytoplasmic DNA that is produced by infection with viral or microbial pathogens, or by tissue damage. AIM2 also appears to be a tumor suppressor, and its inactivation may play a role in the development of cancer, according to Dr. Alnemri
GUMC researchers find gene function "lost" in melanoma and glioblastoma
piggy submitted, created time 1 year 8 months (www.eurekalert.org)
Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers – malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor. They add that because this gene, known as PTPRD, has recently been found to be inactivated in several other cancers as well, their discovery suggests that PTPRD may play a tumor suppressor role in a wide variety of different cancers.
The findings are published in the December 15 issue of Cancer Research
jerry submitted, created time 1 year 11 months (www.reuters.com)
A study find that a variation of the gene for the vitamin D receptor appears to increase the risk of melanoma, a serious and sometimes fatal skin cancer. Patients with the BsmI variant had a 30% higher risk of melanoma, accounting for perhaps 10% of all cases.
Patient, Heal Thyself: Body's Own Immune Cells Whack Late-Stage Tumor
sea-maid submitted, created time 2 years 2 weeks (www.sciam.com)
In what could be a breakthrough in cancer therapy, researchers report in The New England Journal of Medicine today that they succeeded in bolstering a patient's immune system enough to wipe out late-stage malignant tumors on its own. The scientists say the successful experiment could pave the way for new treatments of advanced cancer that spare patients the side effects of chemotherapy, which kills healthy as well as malignant cells.....
Zinc-finger proteins turn T-cells HIV-resistant
Darkfrog submitted, created time 2 years 2 months (www.nature.com)
ZInc-finger proteins occur naturally in human cells and regulate gene activity. Researchers out of California's Sangamo Biosciences have figured out how to use these proteins to disrupt and disable specific genes. The kicker? When the gene in question is CCR5, human T-cells suddenly become resistant to infection with HIV.
At this point, any practical treatment would involve removing (or growing) the patient's own T-cells, treating them with zinc finger proteins, and then re0injecting the patient. Cumbersome, but possible
Melanoma Cured 100% through Blood Cell Therapy
kavin submitted, created time 2 years 2 months (www.efluxmedia.com)
The results of a new study conducted by a researcher team at the Fred Hutchinson Cancer Research Center in Seattle, give hope for those suffering from melanoma, one of the rarer types of skin cancer but the one which causes the majority of skin cancer related deaths.
Researchers who took part in the study used a patient's cloned T cells (helper cells) to put an advanced cancer into complete remission. Nine patients took part in the experimental melanoma treatment program.
The researchers were very surprised after they treated a 52-year-old man from Oregon of his Stage 4 melanoma
Cancers inhibited by embryonic stem cell protein
sumsung submitted, created time 2 years 6 months (www.newscientist.com)
Human embryonic stem cells produce a protein thatshows some anti-cancer properties in the lab, according to a new study. The potential for stem-cell therapies to cause cancer is a major concern, but now researchers at Northwestern University in Chicago, US, say a protein produced by human embryonic stem cells (hESCs) can inhibit the growth and spread of breast cancer and malignant melanoma, the deadliest form of skin cancer.
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
davidd submitted, created time 2 years 6 months (www.pnas.org)
B-RAF is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting "active" protein kinases have demonstrated significant utility in the therapeutic repertoire against cancer. The article represents the entire discovery process of a selective inhibitor , from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-RafV600E-driven tumors.
High expression of DNA repair pathways is associated with metastasis in melanoma patients
davidd submitted, created time 2 years 7 months (www.nature.com)
They find high expression of DNA repair pathways is associated with metastasis in melanoma patients. This overexpression of repair genes explains nicely the extraordinary resistance of metastatic melanoma to chemo- and radio-therapy. Their results may open a new avenue for the discovery of drugs active on human metastatic melanoma.
Immunology submitted, created time 2 years 9 months (www.ncbi.nlm.nih.gov)
CD25CD4 regulatory T cells (Treg) regulate peripheral self-tolerance and possess the ability to suppress antitumor responses, which may explain the poor clinical response of cancer patients undergoing active immunization protocols, and provides the rationale for neutralizing Treg cells in vivo to strengthen local antitumor immune responses. Because interleukin-2 (IL-2) mediates tumor regression in about 15% of treated patients but simultaneously increases Treg cells, we hypothesized that transient elimination of Treg cells will enhance the clinical effectiveness of IL-2 therapy
Melanoma contains CD133 and ABCG2 positive cells
laporta submitted, created time 2 years 10 months (www.elsevier.com)
The authors show three main novelties for human melanoma: firstly, melanoma
biopsy contains a subset of cells expressing CD133 (CD133+) and the latter is able to
develop a Mart-1 positive tumour in NOD-SCID mice. Secondly, the WM115, a human melanoma
cell line, has been found to express both CD133 and ABCG2 markers. As in xenografts generated with CD133+ biopsy melanoma
cells, those produced by the cell line displayed lower levels of CD133 and ABCG2
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