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11

Stem cell research: Obama administration changes some Bush-era restrictions, leaves others in place

Darkfrog submitted, created time 10 months 3 weeks (www.nature.com)

(Yes, I appreciate the irony of using a British journal as a source for U.S. news.)

The National Institutes of Health have spelled out the new state of embryonic stem cell research: Cell lines developed from leftover fertility clinic embryos will be eligible for Federal funding, but the donors (the fertility patients) must provide informed consent with no inducements.

Federal funding is not extended to embryos created specifically for research, including embryos made from donated sperm and ova

12

Creating Ideal Neural Cells for Clinical Use

piggy submitted, created time 11 months 5 days (www.burnham.org)

Investigators at the Burnham Institute for Medical Research (Burnham) have developed a protocol to rapidly differentiate human embryonic stem cells (hESCs) into neural progenitor cells that may be ideal for transplantation. The research, conducted by Alexei Terskikh, Ph.D., and colleagues, outlines a method for creating these committed neural precursor cells (C-NPCs). This method is replicable, does not produce mutations in the cells and could be useful in clinical applications. The research was published on March 13 in the journal Cell Death and Differentiation.

12

Aberrant and ordinary embryonic pathways in leukemic stem cells

sea-maid submitted, created time 11 months 3 weeks (www.nature.com)

A growing body of research in breast cancer, leukemia and brain cancer shows that cancer stem cells co-opt the pathways of regular stem cells to maintain themselves and resist treatments. Two recent studies in acute myeloid leukemia have used very different techniques that each point to the likelihood of uncovering strategies to target cancer stem cells while sparing healthy stem cells.

12

Embryonic stem cells have their own way to deal with viruses

sea-maid submitted, created time 11 months 3 weeks (www.nature.com)

A new zinc finger protein, perhaps the first of many, silences integrated viruses

12

Protein Is Key to Embryonic Stem Cell Differentiation

piggy submitted, created time 1 year 4 hours (www.burnham.org)

Investigators at Burnham Institute for Medical Research (Burnham) have learned that a protein called Shp2 plays a critical role in the pathways that control decisions for differentiation and self-renewal in both human embryonic stem cells (hESCs) and mouse embryonic stem cells (mESCs).

The research, led by Gen-Sheng Feng, Ph.D., differs with some earlier findings that suggested hESCs and mESCs differentiate as a result of different signaling mechanisms

12

Virus-free Embryonic-like Stem Cells Made from Skin of Parkinson's Disease Patients

piggy submitted, created time 1 year 1 week (www.sciencedaily.com)

Whitehead Institute researchers have developed a novel method to remove potential cancer-causing genes during the reprogramming of skin cells from Parkinson's disease patients into an embryonic-stem-cell-like state. Scientists then used the resulting induced pluripotent stem (iPS) cells to derive dopamine-producing neurons, the cell type that degenerates in Parkinson's disease patients.

This marks the first time researchers have generated human iPS cells that have maintained their embryonic stem-cell-like properties after the removal of reprogramming genes

12

President Obama has yet to reverse Bush's ban on Federal funding for embryonic stem cell research

Darkfrog submitted, created time 1 year 3 weeks (www.nature.com)

President Barack Obama has been in office only just over one month, but already scientists are wondering why he has yet to reverse President George W. Bush's ban on the use of federal funds for embryonic stem cell research--this was one of Mr. Obama's campaign promises.

Messages from the White House are mixed. There are rumors that the president's action is being delayed to coincide with pending legislation: There is a bipartisan measure in the House that would allow Federal funding for stem cell lines created from embryos left over from fertility clinics with the patients' permission

12

Don’t go changing: New chemical keeps stem cells young

piggy submitted, created time 1 year 1 month (www.bath.ac.uk)

Scientists at the Universities of Bath and Leeds have discovered a chemical that stops stem cells from turning into other cell types, allowing researchers to use these cells to develop new medical treatments more easily.

Stem cells have the ability to develop into many other cell types in the body, and scientists believe they have huge potential to treat diseases or injuries that don’t currently have a cure

12

Fusing Embryonic Stem Cells with Adult Cells Using Highly Efficient New Fusing System

piggy submitted, created time 1 year 2 months (www.sciencedaily.com)

MIT engineers have developed a new, highly efficient way to pair up cells so they can be fused together into a hybrid cell.

The new technique should make it much easier for scientists to study what happens when two cells are combined. For example, fusing an adult cell and an embryonic stem cell allows researchers to study the genetic reprogramming that occurs in such hybrids

8

Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests

piggy submitted, created time 1 year 2 months (www.eurekalert.org)

Researchers have what they think may be a basic recipe for capturing and maintaining indefinitely the most fundamental of embryonic stem cells from essentially any mammal, including cows, pigs and even humans. Two new studies reported in the December 26th issue of the journal Cell, a Cell Press publication, show that a cocktail first demonstrated to work in mice earlier this year, which includes inhibitory chemicals, also can be used to successfully isolate embryonic stem cells from rats.

Authentic rat embryonic stem cells had never before been established

10

New embryonic stem cells ratted out

sea-maid submitted, created time 1 year 2 months (www.sciencenews.org)

Scientists have finally succeeded in deriving embryonic stem cells from rats, providing the research community with a new tool for modeling human disease. The method used may prove to be a general recipe to create stem cells from many different animals, the researchers say. The findings appear in two companion papers in the Dec. 26 Cell.

10

Pure Insulin-Producing Cells Produced in Mice

piggy submitted, created time 1 year 3 months (www.sciencedaily.com)

Singapore researchers have developed an unlimited number of pure insulin-producing cells from mouse embryonic stem cells (ESCs).

These pure insulin-producing cells, which according to electron microscopy studies, have the same sub-cellular structures as the insulin-producing cells naturally found in the pancreas, were highly effective in treating diabetes in the mouse model.

The transplants of pure insulin-producing cells reduced the blood glucose levels of diabetic mice with high blood glucose levels

11

Angiogenesis: Multipotent tumor endothelial cells

sea-maid submitted, created time 1 year 4 months (www.nature.com)

New blood vessels are required for the growth of tumours, but tumor blood vessels are poorly formed and dysfunctional. Can the properties of tumor endothelial cells (TECs) help us to understand abnormalities in tumor blood vessel formation? A recent study has shown that TECs isolated from mouse prostate tumors are distinct from normal endothelial cells (ECs): they are multipotent, undergo calcification and can differentiate into cartilage- and bone-like tissues. These properties may contribute to the atypical characteristics of tumour blood vessels

15

Testicles could provide "ethical" stem cells

sea-maid submitted, created time 1 year 5 months (www.newscientist.com)

This article provides more information about last week's announcement that researchers have found a form of adult stem cells that appear to be as versatile as embryonic cells ...in men's testicles.

A team out of the University of Tubingen in Germany managed to convert spermatagonial cells into skin, gut structures, cartilage, bone, muscle, and neurons, quite an accomplishment. Some of their colleagues are enthusiastic. Robert Lanza of Advanced Cell Technology in Massachusetts (U.S

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