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12

Sanofi to invest $90 mln in Lantus in China

piggy submitted, created time 10 months 3 weeks (news.bionews.com.cn)

Sanofi-Aventis, the world's fourth-biggest drug maker, will invest $90 million to boost output of the insulin Lantus in China, the company said in a statement on Tuesday.

The new investment follows a $94 million investment that Sanofi made in 2007 to build a manufacturing facility for products that prevent seasonal influenza.

Sanofi said that, taken together, the two investments make it the biggest investor in China's biological field.

10

Your Oral Health Is Connected to Your Overall Health

sea-maid submitted, created time 11 months 1 week (www.sciencedaily.com)

Scientists at the 87th General Session of the International Association for Dental Research, convening today in Miami Beach, report new studies on the connection between oral disease and systemic disease. A recurring theme is the relationship between periodontal (gum) disease and infant prematurity, diabetes, or stroke.

12

US panel: Novo Nordisk tumor data concern for humans

piggy submitted, created time 11 months 2 weeks (www.reuters.com)

Novo Nordisk failed to provide data to show that thyroid tumors in rodents given its experimental diabetes drug would not pose a concern for people treated with the drug, a U.S. advisory panel said in a 12-1 vote on Thursday.

The committee of outside experts was set to vote later on whether the tumor findings should prevent marketing of the drug, liraglutide.

13

Ticking of body's 24-hour clock turns gears of metabolism and aging

piggy submitted, created time 1 year 1 day (www.eurekalert.org)

All animals, including humans, have an internal 24-hour clock or circadian rhythm that creates a daily oscillation of body temperature, brain activity, hormone production and metabolism. Studying mice, researchers at Washington University School of Medicine in St. Louis and Northwestern University found how the biological circadian clock mechanism communicates with processes that govern aging and metabolism

11

Scientists grow diabetes drug in tobacco plants

sea-maid submitted, created time 1 year 1 day (www.reuters.com)

Scientists have found a healthy use for tobacco after breeding genetically modified plants containing interleukin 10, which could interfere with the progression of type 1 diabetes and other autoimmune conditions.

The process of growing medicines through genetically modified plants, called molecular farming, is projected to be cheaper than traditional factory methods. The article also quotes University of Verona scientist Mario Pezzotti as saying that they may also be cheaper than cell cultures--the current standard for antibody medicines

11

Virus said to trigger childhood-onset diabetes

sea-maid submitted, created time 1 year 1 week (news.bbc.co.uk)

U.K. researchers report that enteroviruses may be triggers for type I diabetes, particularly in children. In a study of diabetic children, pancreatic tissue from 60% of the subjects was shown to be infected with enterovirus. Hardly any non-diabetic children showed any enterovirus at all. In adults this figure was closer to 40%.

Type I diabetes is an autoimmune disease in which the body kills off its own beta cells (this is as opposed to type II diabetes, in which the body's insulin receptors are damaged or less sensitive)

10

Drug Combination Reduces Risk of Kidney Disease in Diabetics

sea-maid submitted, created time 1 year 2 weeks (www.sciencedaily.com)

For patients with type two diabetes, a combination of two blood-pressure-lowering drugs reduces the risk of kidney disease by about twenty percent—even in patients who don't have high blood pressure, reports a study in the April 2009 issue of the Journal of the American Society of Nephrology (JASN).

9

On a High-Fat Diet, Protective Gene Variant Becomes Bad Actor

sea-maid submitted, created time 1 year 2 months (www.sciencedaily.com)

New evidence in mice bolsters the notion that a version of a gene earlier shown to protect lean people against weight gain and insulin resistance can have the opposite effect in those who eat a high-fat diet and are heavier, reveals a report in the January 7th issue of the journal Cell Metabolism, a Cell Press publication

9

Obesity Starts in the Head? Six Newly Discovered Genes for Obesity Have a Neural Effect

piggy submitted, created time 1 year 2 months (www.sciencedaily.com)

Obesity is known to increase the risk of chronic disorders, such as diabetes (type 2). An international team of scientists with German participation through the Helmholtz Zentrum München identified six new obesity genes. Gene expression analyses have shown that all six genes are active in brain cells.

The international GIANT (Genetic Investigation of Anthropometric Parameters) consortium works on the discovery of obesity genes. So far, the scientists have analyzed two million DNA variations in fifteen genome-wide association studies with a total of more than 32,000 participants

12

Control of blood vessels a possible weapon against obesity

piggy submitted, created time 1 year 2 months (www.eurekalert.org)

Mice exposed to low temperatures develop more blood vessels in their adipose tissue and metabolize body fat more quickly, according to a new study from Karolinska Institutet. Scientists now hope to learn how to control blood vessel development in humans in order to combat obesity and diabetes.

The growth of fat cells and their metabolism depend on oxygen and blood-borne nutrients. A possible way to regulate the amount of body fat – in order, for instance, to combat obesity – can therefore be to affect the development of blood vessels in the adipose tissue

7

Hope of insulin cell transplant

sea-maid submitted, created time 1 year 2 months (news.bbc.co.uk)

Scientists working towards pancreatic cell transplants as a cure for diabetes have taken the first step to getting around the problem of immune rejection.

7

Obesity Surgery Reverses Diabetes in Teens

sea-maid submitted, created time 1 year 2 months (www.time.com)

Obesity surgery can reverse diabetes in teens, just as it does in adults, according to a small study

12

Of Dreams and Diabetes

piggy submitted, created time 1 year 3 months (sciencenow.sciencemag.org)

Is there a link between sleep and type 2 diabetes? That's one implication of a new study, which has found that variants in a gene that helps regulate the body's daily rhythms increase the chance of developing the disease. The find, reported online yesterday in three papers in Nature Genetics, may suggest new ways to treat or prevent the ever more common disorder.

The body's internal clock--which controls the circadian rhythm--is kept accurate by a hormone called melatonin, whose levels fall during the day and rise at night

12

Clock-gene variants linked to diabetes

sea-maid submitted, created time 1 year 3 months (www.nature.com)

Fresh evidence suggests that melatonin, a hormone that regulates the body's biological clock, is associated with type 2 diabetes.

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